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KMID : 0360419810170010033
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Korean Journal of Pharmacology
1981 Volume.17 No. 1 p.33 ~ p.39
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Influences of Guanethidine and α-Methyl-para-tyrosine on the hepatotoxicity of Carbon tetrachloride
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Abstract
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In this paper, the influences of adrenergic neuronal blockades of different mode: guanethidine and α-methyl-para-tyrosine on the changes induced by carbon tetrachloride (CC14) of hepatic total lipid, glycogen, and lipid peroxide contents and serum lactic dehydrogenase activity were investigated in male mice.
The results obtained were summarized as follows:
1) The hepatic total lipid and lipid peroxide contents and serum lactic dehydrogenase activity were markedly increased by CCl4, but hepatic glycogen content were decreased.
2) The hepatic total lipid and lipid peroxide contents and serum lactic dehydrogenase activity were not significantly changed by guanethidine(20mg/kg) or α-methyl-para-tyrosine (5 mg/kg) injection.
3) The increase of hepatic total lipid induced by CC14 was inhibited by the pretreatment of guanethidine or α-methyl-para-tyrosine, and the increase of hepatic lipid peroxide content induced by CC14 was slightly inhibited by them. But the decrease of hepatic glycogen content and the increase of serum lactic dehydrogenase activity induced by CC14 were not affected by them.
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